% (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. } !1AQa"q2#BR$3br Have an order or account question, find answers in our Online Support articles. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Micro Crystalline Cellulose. MATERIAL SAFETY DATA SHEET. Combines good flow and high compactibility. 1.3. Microcrystalline Cellulose E460 MSDS 1. xv}O2' H~KEe9>G/,:9\i IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. PharmaCentral 2021 . 4 0 obj From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Medium size standard MCC grade, suited for the majority of directly compressible actives. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . q9;v80q>jZ The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. It works as a moisture sponge and permits the controlled growth of spheroids. 8 0 obj 4 0 obj Gloves, eye protection and a dust mask should be used. 1.3. By producing Avicel . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. SDS. SUBSTANCE IDENTIFICATION 1.1. Eur., JPE . ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. MATERIAL SAFETY DATA SHEET Version: 1.0 1. EINECS #: 232-674-9 1.7. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. FMC Corporation. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. 0.25 - 0.37. MATERIAL SAFETY DATA SHEET. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Explore how we work and why we apply science and creativity for a better world to everything we do. FMC, JRS and Mingtai were estimated to hold for . {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. In large quantities it provides dietary bulk and may lead to a laxative effect. In 1964 FMC, Corporation . 51395-75-6 Avicel RC 591. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . }o]X4]. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Microcrystalline Cellulose / Avicel PH-102. 2008-2023 ChemPoint. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Chemical Formula: (C6H10O5)n 1.4. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Some substance identifiers may have been claimed confidential, or may . Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. >> Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. No. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. 102331. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. /Resources 2 0 R PDF (2.77 mb) 2021 FMC Sustainability Report. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. 1. : 9004-34-6 Date Approved: 01/31/2008 . As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. ( Microcrystalline Cellulose NF. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Synergies to simplify formulation challenges and reduce operational costs. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). <> As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. In extrusion-spheronisation, it is the excipient of choice. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. 1 0 obj pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. A., and Smith, P. A. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. The table below shows the most common physicochemical parameters of this raw material. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. : CL-611NF Date Approved: 01/13/2010. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . /MediaBox [0 0 612 792] Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. X\o^ Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. gwf;J(e0o|1p{R~P^);ao!%{0KD7. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. The aqueous solution to barrier membrane coating. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication The cellulose molecule is formed through repeated condensation of cellobiose units. Avicel Microcrystalline Cellulose: Chemical Identifiers. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. JFIF ` ` ZExif MM * J Q Q Q C It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. SDS - Safety Data Sheet. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. % Explore how you can develop your career and bring your creative ideas to life at IFF. No. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Remove Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Product and Company Identification . Validity Area. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Thus, Avicel contributes no or very few calories to the food system. Synonyms: Cellulose, Cellulose powder, Cotton linters. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. %PDF-1.4 Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. PDF (28.38 mb) 2022 Corporate Fact Sheet. Millipore. stream cas:9000-11-7 msds Carboxymethyl cellulose. CAS #: 9004-34-6 . The short-term limit for total inhalable dust is 20 mg/m3. The most. ( lH5JWy}DgKRR"Fs We respect your privacy FMC Privacy Policy. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. SUBSTANCE IDENTIFICATION 1.1. Safety Data Sheet for Cellulose microcrystalline 102331. There may be more fiber in your food than you realized. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. 2021 Annual Report. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Watch Now. Product Name: Microcrystalline Cellulose 1.2. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. CoA. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . >> Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. HMo@9, U Q!R/1*;` Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. An agricultural sciences company. Van Veen, G.K. Bolhuis, Y.S. These grades have particle sizes ranging from <30 to approximately 200. Delivering efficient and robust formulations. LOT #: Available upon request. 1 0 obj q86@on$^X_HuH;3` gac74 [#B6`Wnw7 Avicel PC 611 (FMC Biopolymer) Supplied by. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Origin(s): Plant/Botanical. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . CAS #: 9004-34-6 1.6. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. A family of polysaccharide products that allow distinctive drug delivery solutions. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals.
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